Einstein International Journal Organization(EIJO)

Abstract

Curcumin, a natural polyphenolic compound derived from turmeric, has attracted significant scientific interest due to its potent antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. However, its clinical application is limited by poor aqueous solubility, rapid metabolism, low bioavailability, and instability under physiological conditions. Nanotechnology-based delivery systems have emerged as promising strategies to overcome these limitations by enhancing solubility, protecting curcumin from degradation, and improving targeted delivery. Various nanoparticle formulations, including polymeric nanoparticles, lipid-based nanoparticles, nanoemulsions, liposomes, and inorganic nanocarriers, have demonstrated improved therapeutic efficacy in preclinical and clinical studies. These systems facilitate controlled drug release, enhanced cellular uptake, and site-specific targeting, thereby improving pharmacokinetic and pharmacodynamic profiles. Despite encouraging progress, challenges related to large-scale production, long-term safety, regulatory approval, and clinical translation remain. Continued research integrating advanced formulation strategies and translational studies is essential to fully realize the therapeutic potential of curcumin-loaded nanoparticles in modern medicine.

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